How does cf affect the sweat glands

ABC family members perform several tasks, including energy-dependent transmembrane transport of large molecules, regulation of other transmembrane transporters, and the transport of ions across membranes.

CFTR displays at least two of these functions. It is an anion channel that uses the energy of ATP hydrolysis to transit through conducting and non-conducting conformations. Ion channels are equally adept at allowing ions to flow either into or out of cells, enabling the CFTR anion channel to play crucial roles in both absorption and secretion.

Nonetheless, defective sweating soon became an inseparable, and major, component of the constellation of symptoms that diagnose "cystic fibrosis" Davis PB. The sweat gland has played a foremost role in diagnosing, defining pathophysiology, debunking misconceptions, and increasing our understanding of the effects of the disease on organs, tissues, cells, and molecules.

The sweat gland has taught us much. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Topic Overview Cystic fibrosis can lower the normal salt levels in the body, which can lead to a variety of short- and long-term problems. Current as of May 4, Current as of: May 4, Search the Healthwise Knowledgebase.

Help Healthwise Index. Kids who have CF are at risk for repeated lung infections. The sweat test measures the amount of chloride in sweat.

Kids with cystic fibrosis can have two to five times the normal amount of chloride in their sweat. In a sweat test, the skin is stimulated to produce enough sweat to be absorbed into a special collector and then analyzed. Doctors may test an infant suspected of having cystic fibrosis as early as 48 hours after birth, though any test done during a baby's first month might need to be repeated because newborns may not produce enough sweat to ensure reliable results.

Doctors will order a chloride sweat test for kids with positive newborn screen for cystic fibrosis, a family history of cystic fibrosis, or symptoms of the disorder. Symptoms and signs include failure to grow, repeated lung infections, and digestive problems. No special preparation is necessary for this test. Before having this test, your child may eat, drink, and exercise as usual, and continue to take any current medicines.

Creams and lotions should not be applied to the skin 24 hours before the procedure. A sweat test usually takes about an hour, so you may want to bring books or toys to help your child pass the time.